Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.

@article{Hostert1998HierarchicalIO,
  title={Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.},
  author={Arnd Hostert and Anna Garefalaki and Georgia Mavria and Mauro Tolaini and Kathleen Roderick and Trisha Norton and Patrick J. Mee and Victor L. J. Tybulewicz and Mark A Coles and Dimitris Kioussis},
  journal={Immunity},
  year={1998},
  volume={9 4},
  pages={497-508}
}
CD4 and CD8 are crucial for the development and function of T cells. An intergenic deoxyribonuclease I hypersensitive site region (cluster CIII) directs expression in mature CD8 T cells only. Here, we show that two further independent regions from the CD8 gene locus in conjunction with cluster CIII restore transgene expression in appropriate immature thymocytes. Deletion of two of the intergenic cluster CIII DNaseI-HSS in homozygous mutant mice affects expression of CD8alphaalpha homodimers on… CONTINUE READING

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