Hierarchical Structure of Articular Bone‐Cartilage Interface and Its Potential Application for Osteochondral Tissue Engineering

@inproceedings{Bian2010HierarchicalSO,
  title={Hierarchical Structure of Articular Bone‐Cartilage Interface and Its Potential Application for Osteochondral Tissue Engineering},
  author={Weiguo Bian and Lian Qin and Dichen Li and Jiachun Wang and Zhongmin Jin},
  year={2010}
}
The artificial biodegradable osteochondral construct is one of mostly promising lifetime substitute in the joint replacement. And the complex hierarchical structure of natural joint is important in developing the osteochondral construct. However, the architecture features of the interface between cartilage and bone, in particular those at the micro‐and nano‐structural level, remain poorly understood. This paper investigates these structural data of the cartilage‐bone interface by micro… Expand
1 Citations

References

SHOWING 1-10 OF 15 REFERENCES
A three-dimensional osteochondral composite scaffold for articular cartilage repair.
TLDR
A unique, heterogeneous, osteochondral scaffold is developed using the TheriForm three-dimensional printing process, suggesting that these scaffolds have desirable mechanical properties for in vivo applications, including full joint replacement. Expand
Engineered osteochondral grafts using biphasic composite solid free-form fabricated scaffolds.
TLDR
A combination of IBD and SFF-fabricated biphasic scaffolds with gene and cell therapy is a promising approach to regenerate osteochondral defects. Expand
Osteochondral tissue engineering.
TLDR
In order to introduce the use of engineered osteochondral composites in the routine clinical practice, it will be necessary to comprehensively address a number of critical issues, including those related to the size and shape of the graft to be generated, the cell type and properties of the scaffold to be used, the potential physical conditioning to be applied, the degree of functionality required, and the strategy for a cost-effective manufacturing. Expand
In vitro generation of osteochondral composites.
TLDR
It is demonstrated that osteochondral tissue composites for potential use in osteochondrals repair can be engineered in vitro by culturing mammalian chondrocytes and periosteal cells on appropriate polymer scaffolds. Expand
Design of graded biomimetic osteochondral composite scaffolds.
TLDR
This work developed a composite material with cues which are biomimetic of an osteochondral tissue and with the capacity to differentially support cartilage and bone tissue generation, and warrant testing of the material as a substitute for the repair of osteochondrals lesions in orthotopic animal models. Expand
Porous three-dimensional scaffolds made of mineralised collagen: Preparation and properties of a biomimetic nanocomposite material for tissue engineering of bone
For healing of bone defects and as matrix for tissues engineering, porous scaffolds are required that can be easily pre-seeded with cells in the lab and invaded by tissue after implantation. We haveExpand
Biphasic, but monolithic scaffolds for the therapy of osteochondral defects
Abstract For the regenerative therapy of osteochondral defects – deep lesions of the articular cartilage in which the underlying bone tissue is already affected too – special implant materials andExpand
Evaluation of multiphase implants for repair of focal osteochondral defects in goats.
TLDR
This investigation demonstrates that focal, osteochondral defects in caprine distal femurs treated with various implant constructs were repaired with hyaline-like cartilage and good underlying bone. Expand
Construction of tissue engineered osteochondral composite
Objective To explore the feasibility of construction of a osteochndral composite using tissue engineering technology.Methods Cartilage constructs were created by seeding bone marrow stromal cellsExpand
Bi-layered constructs based on poly(L-lactic acid) and starch for tissue engineering of osteochondral defects
Abstract Articular cartilage has a limited capacity to repair itself, and conventional therapeutic approaches have shown to have limited success as they are deficient and inconsistent in long-termExpand
...
1
2
...