Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design.

@article{Cui2016HierarchicalFO,
  title={Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design.},
  author={Haitao Cui and Wei Zhu and Margaret Nowicki and Xuan Zhou and Ali Khademhosseini and Lijie Grace Zhang},
  journal={Advanced healthcare materials},
  year={2016},
  volume={5 17},
  pages={
          2174-81
        }
}
A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events. 
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