Hierarchical Bayesian approaches to phase II trials in diseases with multiple subtypes.

@article{Thall2003HierarchicalBA,
  title={Hierarchical Bayesian approaches to phase II trials in diseases with multiple subtypes.},
  author={Peter F. Thall and J. Kyle Wathen and Benjamin Nebiyou Bekele and Richard E. Champlin and Laurence H. Baker and Robert S Benjamin},
  journal={Statistics in medicine},
  year={2003},
  volume={22 5},
  pages={763-80}
}
We propose a methodology for conducting phase II clinical trials in settings where the disease is categorized into multiple subtypes. A hierarchical Bayesian model is assumed for treatment effects within the subtypes. The hierarchical model, which is tailored to each particular application, allows treatment effects to differ across subtypes while assuming a… CONTINUE READING