Hidradenitis Suppurativa: Advances in Diagnosis and Treatment

@article{Saunte2017HidradenitisSA,
  title={Hidradenitis Suppurativa: Advances in Diagnosis and Treatment},
  author={Ditte Marie Lindhardt Saunte and Gregor Borut Ernst Jemec},
  journal={JAMA},
  year={2017},
  volume={318},
  pages={2019–2032}
}
Importance Hidradenitis suppurativa (HS) is relatively common, with the prevalence of 0.05% to 4.10%, yet many patients receive inadequate treatment. [...] Key Method Evidence Review A literature search was conducted using PubMed, MEDLINE (Medical Subject Headings [MeSH]), and EMBASE to include recently published treatment studies (searched from September 1, 2011, to May 1, 2017). Reviews, guidelines, conference abstracts, and studies with less than 10 patients were excluded.Expand

Paper Mentions

Interventional Clinical Trial
Hidradenitis suppurativa (HS) is a common chronic skin disease where patients experience inflamed painful nodules and chronic suppurating tunnels under the skin that often leave… Expand
ConditionsHidradenitis Suppurativa
InterventionProcedure
Severe forms of hidradenitis suppurativa with complications in the anogenital area
TLDR
It is reported that anogenital HS has the strongest negative impact on quality of life due to pain, secretions, and mobility issues, and to the inefficacy of common systemic treatments. Expand
Pharmacological development in hidradenitis suppurativa.
TLDR
TNF inhibition with adalimumab remains the only EMA-approved/FDA-approved agent in HS treatment and should be consequently considered first, while several new biologics are being investigated, including MABp1 (bermekimab), CJM112, bimekizumab, guselkumAB, secukinumab and IFX-1. Expand
A hidradenitis suppurativa nőgyógyászati vonatkozásai
TLDR
Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicles, usually presenting after puberty on the apocrine gland-bearing areas of the body, and is not only a dermatological, but also a gynecological disease. Expand
Hidradenitis suppurativa: Basic considerations for its approach: A narrative review
TLDR
Hidradenitis suppurativa is a chronic and debilitating skin disease, whose lesions can range from inflammatory nodules to abscesses and fistulas in the armpits, groin, perineum, inframammary region, and it is necessary for general practitioners to have basic knowledge about this entity. Expand
Multidisciplinary Update on Genital Hidradenitis Suppurativa: A Review.
TLDR
A variety of reconstructive techniques based on the size and location of the skin deficiency are described, which require a thorough understanding of medical and surgical techniques for prevention, treatment, and reconstruction of genital defects. Expand
Challenging treatment of hidradenitis suppurativa with happy ending
TLDR
Hydradenitis supurativa is a chronic, recurrent and inflammatory disease which involves skin and subcutaneous fatty tissue and is most commonly involved in axilla, inguinal and perianal regions. Expand
Case report: Unusual complications of severe hidradenitis suppurativa
TLDR
An 18-year-old female diagnosed with bilateral axillary HS/AI presented in 2017 with advanced Hurley stage III disease, and subsequently went into septic shock, and died in the intensive care unit. Expand
Factors Affecting Healing in the Treatment of Hidradenitis Suppurativa.
TLDR
Participation in a multidisciplinary program is a strong predictor of long-term success when treating HS and Hurley score and number of involved sites did not correlate with successful healing after surgery. Expand
Hidradenitis suppurativa in Korea
  • G. Jemec
  • Medicine
  • Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2018
TLDR
This important study reinforces the impression that reported population HS prevalence rates appear influenced by the methodology used to gather the data, and describes the clinical epidemiology of Hidradenitis suppurativa in Korea in a nationwide registry study using the Korean NHI claim database data from 2007 to 2016. Expand
Incidence and Prevalence of Hidradenitis Suppurativa: A Systematic Review and Meta-analysis
TLDR
The global prevalence of HS is estimated to be 0.36% with 3:2 female predominance and average annual incidence to be 28.5 cases/100,000, which is more prevalent in women. Expand
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References

SHOWING 1-10 OF 94 REFERENCES
Interventions for hidradenitis suppurativa.
TLDR
The primary outcomes were quality of life, measured by a validated dermatology-specific scale, and adverse effects of the interventions, and many knowledge gaps exist in RCT evidence for HS. Expand
Hidradenitis suppurativa: Epidemiology and scope of the problem.
TLDR
The epidemiology of HS is addressed through current available research and comparisons between HS and psoriasis are worth mentioning because the similarities are clear, but the severity of HS appears to be more debilitating in many aspects of life. Expand
Diagnostic delay in hidradenitis suppurativa is a global problem
TLDR
This study explores the delay in diagnosis for patients with HS on an international level and quantifies thedelay in diagnosis of HS compared with psoriasis with/without a family history. Expand
Surgical Management of Hidradenitis Suppurativa
TLDR
Conservative treatment methods have little or no effects on gluteal, perineal/perianal, axillary hidradenitis suppurativa, and the only successful treatment is wide surgical excision. Expand
An Update on Medical Treatment Options for Hidradenitis Suppurativa
TLDR
An overview of most drug treatments reported on for HS is provided, where possible with their mode of action and side effects, and surgical interventions are often needed to achieve remission. Expand
The prevalence of hidradenitis suppurativa and its potential precursor lesions.
TLDR
Hidradenitis suppurativa is significantly more common than hitherto estimated, and the female preponderance of patients is confirmed, except for patients with axillary lesions. Expand
Recurrence of hidradenitis suppurativa after surgical management: A systematic review and meta-analysis.
TLDR
A systematic review of surgical approaches in the management of Hidradenitis suppurativa found lower recurrence rates with wide excision, using skin flaps or skin grafts as the closure methods. Expand
Efficacy of ertapenem in severe hidradenitis suppurativa: a pilot study in a cohort of 30 consecutive patients.
TLDR
Ertapenem can dramatically improve severe HS and are mandatory to prevent relapses, combined with surgery, optimized antibiotic treatments may be promising in severe HS. Expand
A review of wide surgical excision of hidradenitis suppurativa
TLDR
Elimination of the acute inflammatory process should occur in advance, including the use of antibiotics and minor surgeries such as abscess drainage with proper irrigations and planning of surgical reconstruction should be initiated to achieve the best outcome and consequently decreasing the risk of recurrence and complications after surgery. Expand
Surgical Management of Hidradenitis Suppurativa: A 14-Year Retrospective Review of 98 Consecutive Patients
TLDR
Ablative excision of HS-affected skin and wound closure with split-thickness skin grafts is a safe, reliable, and effective therapy. Expand
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