Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways.

@article{Lydall2003HidingAT,
  title={Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways.},
  author={David A. Lydall},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 20},
  pages={4057-65}
}
Telomeres stabilise DNA at the ends of chromosomes, preventing chromosome fusion and genetic instability. Telomeres differ from double strand breaks in that they activate neither DNA repair nor DNA damage checkpoint pathways. Paradoxically DNA repair and checkpoint genes play critical roles in telomere stability. Recent work has provided insights into the roles of DNA repair and DNA damage checkpoint pathways in the physiological maintenance of telomeres and in cellular responses when telomeres… CONTINUE READING

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