Hide-and-seek: the challenge of viral persistence in HIV-1 infection.

  title={Hide-and-seek: the challenge of viral persistence in HIV-1 infection.},
  author={Luc Geeraert and Guenter Kraus and Roger J. Pomerantz},
  journal={Annual review of medicine},
The success of highly active antiretroviral therapy (HAART) for HIV-1 infection has sparked interest in mechanisms by which the virus can persist despite effectively suppressive therapy. Latent HIV-1 reservoirs established early during infection not only prevent sterilizing immunity but also represent a major obstacle to virus eradication. When HIV-1 gains a foothold in the immunologic memory or in certain inaccessible compartments of the human body, it cannot be easily purged by HAART and is… CONTINUE READING

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