Hidden Questions on Methotrexate

  title={Hidden Questions on Methotrexate},
  author={S. Lee},
  journal={Journal of Reproduction and Development},
  • S. Lee
  • Published 2012
  • Medicine
  • Journal of Reproduction and Development
Since the 1950’s, methotrexatehas been the most widely used for the treatment of rheumatoid arthritis among various disease-modifying anti-rheumatic drugs (DMARDs). In this review, several hidden questions on methotrexate were discussed. First, so far, methotrexate has been considered to improve rheumatoid arthritis by inhibiting cell proliferation through the reduction of synthesis regarding purine and pyrimidine. Recently, a new concept was proposed that methotrexate could increase the… Expand
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