Hidden Markov models approach to the analysis of array CGH data

  title={Hidden Markov models approach to the analysis of array CGH data},
  author={Jane Fridlyand and Antoine Snijders and Dan Pinkel and Donna Albertson and Ajay N. Jain},
The development of solid tumors is associated with acquisition of complex genetic alterations, indicating that failures in the mechanisms that maintain the integrity of the genome contribute to tumor evolution. Thus, one expects that the particular types of genomic alterations seen in tumors reflect underlying failures in maintenance of genetic stability, as well as selection for changes that provide growth advantage. In order to investigate genomic alterations we are using microarray-based… CONTINUE READING
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