Hidden Markov Chains and the Analysis of Genome Structure

@article{Churchill1992HiddenMC,
  title={Hidden Markov Chains and the Analysis of Genome Structure},
  author={Gary A. Churchill},
  journal={Computers & Chemistry},
  year={1992},
  volume={16},
  pages={107-115}
}
In this paper, statistical methods based on a hidden Markov chain model {Churchill1989) are used to study the structure of some small complete genomes and a human genome segment. A variety of discrete compositional domains are discovered and their correlations with genome function are explored. 

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