Hidden Dimensions of Vibrio cholerae Pathogenesis Newer techniques help in analyzing growth of this microorganism in the intestinal tract and in identifying candidate vaccine antigens

@inproceedings{Osorio2003HiddenDO,
  title={Hidden Dimensions of Vibrio cholerae Pathogenesis Newer techniques help in analyzing growth of this microorganism in the intestinal tract and in identifying candidate vaccine antigens},
  author={Gonzalo Osorio and Andrew Camilli},
  year={2003}
}
S tudying microbial virulence factors during infections requires care. Because the microbes recovered from infected tissues are in small number, the factors being sought can easily disappear, be lost, or be overlooked, even if those cells are immediately grown in vitro to try to produce more of those factors for study. Indeed, detecting in vivo-induced virulence factors is subject to a kind of uncertainty principle, whereby analytic procedures might perturb or even destroy the system. What… CONTINUE READING