Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.

@article{Ross1992HibernomaFI,
  title={Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.},
  author={Susan R Ross and Lisa Choy and Rochelle A. Graves and Norma Fox and V Solevjeva and Susanne Klaus and Daniel Ricquier and Bruce M. Spiegelman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 16},
  pages={7561-5}
}
Transgenic mice were produced containing the adipocyte-specific regulatory region from the adipocyte P2 (aP2) gene linked to the simian virus 40 transforming genes. Most of the transgenic mice developed brown fat tumors (hibernomas) in their interscapular brown adipose tissue. Hibernoma formation was noticeable in some of the mice as early as 1 day after birth and most of the mice developed very large tumors by 1 month of age. All of the tumor tissue expressed the brown fat-specific uncoupling… CONTINUE READING
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