Hibernation-based blood loss therapy increases survivability of lethal hemorrhagic shock in rats

@article{Rodriguez2017HibernationbasedBL,
  title={Hibernation-based blood loss therapy increases survivability of lethal hemorrhagic shock in rats},
  author={Cecilia E Perez de Lara Rodriguez and Lester R Drewes and Matthew T Andrews},
  journal={Journal of Comparative Physiology B},
  year={2017},
  volume={187},
  pages={769-778}
}
A small-volume (1 ml/kg) resuscitation fluid based on metabolic adaptations in hibernating mammals was optimized using a rat model of hemorrhagic shock. A previous study of this therapy tested only one concentration of three specific components: 4 M D-stereoisomer of beta-hydroxybutyrate (BHB), 43 mM melatonin, and 20% DMSO. In this study, we considered the range of concentrations of BHB and melatonin seen during the physiological extremes of rapid arousal from hypothermic torpor in natural… CONTINUE READING

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