Hibernating myocardium: high or low risk?

  title={Hibernating myocardium: high or low risk?},
  author={J. McGowan},
  pages={237 - 238}
The optimal strategy for risk stratification in heart failure continues to evolve, with increasing numbers of tools such as natriuretic peptide assessment being utilised The assessment of risk, and its subsequent manipulation, accounts for a large amount of what we do in cardiology. Among the heart failure population, increasing numbers of tools are being utilised for the purpose. In this issue of Heart , Schinkel and colleagues1 present data on the combined use of both physiological and… Expand


B-Type Natriuretic Peptide Predicts Sudden Death in Patients With Chronic Heart Failure
This study tests BNP levels as a predictor of sudden death in patients with chronic heart failure and finds that B-type natriuretic peptide has prognostic significance in CHF. Expand
Relation between left ventricular contractile reserve during low dose dobutamine echocardiography and plasma concentrations of natriuretic peptides
Plasma natriuretic peptide concentrations are raised in patients with left ventricular dysfunction, but in the presence of preserved myocardial contractile reserve, relatively low levels of ANP and BNP are present. Expand
Radioimmunometric assay of natriuretic peptide type-B (BNP) in heart failure
It can be concluded that BNP levels (by radioimmunometric assay) are increased in patients with heart failure, and increase in relation to left ventricular dysfunction and the severity of heart failure. Expand
Dobutamine echocardiography in myocardial hibernation. Optimal dose and accuracy in predicting recovery of ventricular function after coronary angioplasty.
The wall motion response during dobutamine echocardiography is useful in the prediction of recovery of ventricular function after revascularization in patients with stable coronary artery disease and ventricular dysfunction. Expand
B-type natriuretic peptide predicts future cardiac events in patients presenting to the emergency department with dyspnea.
BNP levels measured in patients presenting with dyspnea to the ED are highly predictive of cardiac events over the next 6 months, and were also predictive of CHF events in subsets of patients with positive CHF histories and ED diagnoses. Expand
Prognostic value of myocardial ischemia and viability in patients with chronic left ventricular ischemic dysfunction.
Subgroup analyses indicated that among patients with 1- or 2-vessel disease, only those with ischemic or viable myocardium improved survival after revascularization, whereas in patients with 3-vessels or left main diseases, revascularized always improved survival, albeit more in the presence of ischemia or viableMyocardium. Expand
B-type natriuretic peptide in cardiovascular disease
Measurement of circulating concentrations of B-type natriuretic peptide and the N-terminal fragment of its prohormones and use of recombinant human BNP (nesiritide) and vasopeptidase inhibitors to treat heart failure are focused on. Expand
Pathophysiology of chronic left ventricular dysfunction. New insights from the measurement of absolute myocardial blood flow and glucose utilization.
The results suggest that resting MBF measured with 15O-labeled water in chronically dysfunctional segments is not reduced and that the myocardium of these patients is less sensitive to insulin than that of normal subjects. Expand
Dobutamine echocardiography and quantitative rest-redistribution 201Tl tomography in myocardial hibernation. Relation of contractile reserve to 201Tl uptake and comparative prediction of recovery of function.
In patients with myocardial hibernation, biphasic response during dobutamine is less sensitive but more specific for recovery of function, whereas indexes of 201Tl scintigraphy are in general more sensitive and less specific, the least accurate being a qualitative assessment of thallium uptake. Expand
Reliability of reporting left ventricular systolic function by echocardiography: a systematic review of 3 methods.
No method appears to systematically under- or overestimate LVEF to any major extent, and these findings have important implications for the investigation of heart failure and for the practice and reporting of echocardiography. Expand