Hibernating bear serum hinders osteoclastogenesis in-vitro

  title={Hibernating bear serum hinders osteoclastogenesis in-vitro},
  author={Alireza Nasoori and Yuko Okamatsu-Ogura and Michito Shimozuru and Mariko Sashika and Toshio Tsubota},
  journal={PLoS ONE},
Bears do not suffer from osteoporosis during hibernation, which is associated with long-term inactivity, lack of food intake, and cold exposure. However, the mechanisms involved in bone loss prevention have scarcely been elucidated in bears. We investigated the effect of serum from hibernating Japanese black bears (Ursus thibetanus japonicus) on differentiation of peripheral blood mononuclear cells (PBMCs) to osteoclasts (OCs). PBMCs collected from 3 bears were separately cultured with 10… Expand
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