HgEDTA Complex Inhibits GTP Interactions with the E-Site of Brain β-Tubulin

  title={HgEDTA Complex Inhibits GTP Interactions with the E-Site of Brain $\beta$-Tubulin},
  author={E. Duhr and J. Pendergrass and J. Slevin and B. Haley},
  journal={Toxicology and Applied Pharmacology},
We have found that EDTA and EGTA complexes of Hg2+, which conventional wisdom has assumed are biologically inert, are potentially injurious to the neuronal cytoskeleton. Tubulin, a major protein component of the neuronal cytoskeleton, is the target of multiple toxicants, including many heavy metal ions. Among the mercurials, inorganic mercuric ion (Hg2+) is one of the most potent inhibitors of microtubule polymerization both in vivo and in vitro. In contrast to other heavy metals, the capacity… Expand
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  • S. Cedrola, G. Guzzi, +4 authors C. L. La Porta
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2003