Hg2+ and Cd2+ interact differently with biomimetic erythrocyte membranes

  title={Hg2+ and Cd2+ interact differently with biomimetic erythrocyte membranes},
  author={Mary Trang Le and J{\"u}rgen Gailer and Elmar J Prenner},
In order to characterize the potentially deleterious effects of toxic Hg2+ and Cd2+ on lipid membranes, we have studied their binding to liposomes whose composition mimicked erythrocyte membranes. Fluorescence spectroscopy utilizing the concentration dependent quenching of Phen Green™ SK by Hg2+ and Cd2+ was found to be a sensitive tool to probe these interactions at metal concentrations ≤1 μM. We have systematically developed a metal binding affinity assay to screen for the interactions of Hg2… CONTINUE READING


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