Hg2+ and Cd2+ interact differently with biomimetic erythrocyte membranes

@article{Le2008Hg2AC,
  title={Hg2+ and Cd2+ interact differently with biomimetic erythrocyte membranes},
  author={Mary Trang Le and J{\"u}rgen Gailer and Elmar J Prenner},
  journal={BioMetals},
  year={2008},
  volume={22},
  pages={261-274}
}
In order to characterize the potentially deleterious effects of toxic Hg2+ and Cd2+ on lipid membranes, we have studied their binding to liposomes whose composition mimicked erythrocyte membranes. Fluorescence spectroscopy utilizing the concentration dependent quenching of Phen Green™ SK by Hg2+ and Cd2+ was found to be a sensitive tool to probe these interactions at metal concentrations ≤1 μM. We have systematically developed a metal binding affinity assay to screen for the interactions of Hg2… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Reactive selenium metabolites as targets of toxic metals / metalloids in mammals : a molecular toxicological perspective

  • J Gailer
  • Appl Organomet Chem
  • 2007
Highly Influential
4 Excerpts

Interactions of inorganic mercury with phospholipid micelles and model membranes . A P31NMR study

  • L Girault, A Boudou, EJ Dufourc
  • Eur Biophys J Biophys Lett
  • 1998
Highly Influential
8 Excerpts

Effects of trace elements on membrane fluidity

  • L Girault, P Lemaire, A Boudou, JC Debouzy, EJ Dufourc
  • J Trace Elem Med Biol
  • 1996
Highly Influential
4 Excerpts

Metal complexes of glutathione and their biological significance

  • DL Rabenstein
  • 1989
Highly Influential
3 Excerpts

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