Hfq-dependent, co-ordinate control of cyclic diguanylate synthesis and catabolism in the plague pathogen Yersinia pestis.

@article{Bellows2012HfqdependentCC,
  title={Hfq-dependent, co-ordinate control of cyclic diguanylate synthesis and catabolism in the plague pathogen Yersinia pestis.},
  author={Lauren E. Bellows and Benjamin J Koestler and Sara M Karaba and Christopher M. Waters and Wyndham W Lathem},
  journal={Molecular microbiology},
  year={2012},
  volume={86 3},
  pages={661-74}
}
Yersinia pestis, the cause of the disease plague, forms biofilms to enhance flea-to-mammal transmission. Biofilm formation is dependent on exopolysaccharide synthesis and is controlled by the intracellular levels of the second messenger molecule cyclic diguanylate (c-di-GMP), but the mechanisms by which Y. pestis regulates c-di-GMP synthesis and turnover are not fully understood. Here we show that the small RNA chaperone Hfq contributes to the regulation of c-di-GMP levels and biofilm formation… CONTINUE READING
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