Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin.

@article{Miranda2003HfeDI,
  title={Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin.},
  author={Carlos J. Miranda and Hortence Makui and Ricardo Jos{\'e} Bentim Soares and Marc Bilodeau and Jeannie Mui and Hajatollah Vali and Richard Bertrand and Nancy Catherine Andrews and Maur{\'i}cio G. M. Santos},
  journal={Blood},
  year={2003},
  volume={102 7},
  pages={
          2574-80
        }
}
The clinical use of doxorubicin (DOX), an anthracycline chemotherapeutic agent, is limited by cardiotoxicity. The possible involvement of iron in DOX-induced cardiotoxicity became evident from studies in which iron chelators were shown to be cardioprotective. Iron overload is found in hereditary hemochromatosis, a genetic disorder prevalent in individuals of European descent. We hypothesized that Hfe deficiency may increase susceptibility to DOX-induced toxicity. Acute cardiotoxicity and iron… CONTINUE READING

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