Hey1, a mediator of notch signaling, is an androgen receptor corepressor.

@article{Belandia2005Hey1AM,
  title={Hey1, a mediator of notch signaling, is an androgen receptor corepressor.},
  author={Borja Belandia and Sue M. Powell and Juana M Garc{\'i}a-Pedrero and Marjorie M Walker and Charlotte L Bevan and Malcolm G. Parker},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 4},
  pages={1425-36}
}
Hey1 is a member of the basic helix-loop-helix-Orange family of transcriptional repressors that mediate Notch signaling. Here we show that transcription from androgen-dependent target genes is inhibited by Hey1 and that expression of a constitutively active form of Notch is capable of repressing transactivation by the endogenous androgen receptor (AR). Our results indicate that Hey1 functions as a corepressor for AF1 in the AR, providing a mechanism for cross talk between Notch and androgen… CONTINUE READING

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