Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes.

  title={Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes.},
  author={Charles J Woodrow and Richard J. Burchmore and Sanjeev Krishna},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 18},
Plasmodium falciparum requires glucose as its energy source to multiply within erythrocytes but is separated from plasma by multiple membrane systems. The mechanism of delivery of substrates such as glucose to intraerythrocytic parasites is unclear. We have developed a system for robust functional expression in Xenopus oocytes of the P. falciparum asexual stage hexose permease, PfHT1, and have analyzed substrate specificities of PfHT1. We show that PfHT1 (a high-affinity glucose transporter, K… CONTINUE READING
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