Hexosamines and nutrient excess induce leptin production and leptin receptor activation in pancreatic islets and clonal beta-cells.

@article{Emilsson2001HexosaminesAN,
  title={Hexosamines and nutrient excess induce leptin production and leptin receptor activation in pancreatic islets and clonal beta-cells.},
  author={Valur Emilsson and Jacqueline F. O’Dowd and Anna L Nolan and Michael Anthony Cawthorne},
  journal={Endocrinology},
  year={2001},
  volume={142 10},
  pages={
          4414-9
        }
}
Activation of the hexosamine biosynthesis pathway leads to insulin resistance in muscle and adipose tissue. In these tissues leptin gene expression is increased by glucosamine. In the present study we found that glucosamine rapidly activates the production of leptin and OB-Rb, which encodes the functional leptin receptor, in both primary pancreatic islets and clonal beta-cells. Secretion of leptin from clonal beta-cells into the medium was detected readily. In addition, the level of the… Expand
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