Hexosamine pathway activation and O-linked-N-acetylglucosamine: novel mediators of endothelial dysfunction in hyperglycemia and diabetes.

A number of complex interactions between kidney, blood vessels, heart and brain regulate blood pressure. Dysfunction of any one of them can result in a pathological vascular changes including hypertension. One common mediator among several of these organ systems is the ubiquitous release of nitric oxide (NO) from the vascular endothelium. Substantial… CONTINUE READING