Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells.

@article{Sage2010HexosamineBP,
  title={Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells.},
  author={Andrew T. Sage and Lisa A Walter and Yuanyuan Shi and Mohammad I Khan and Hideaki Kaneto and Alfredo Capretta and Geoff H Werstuck},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={298 3},
  pages={E499-511}
}
There is increasing evidence that endoplasmic reticulum (ER) stress contributes to the development of atherosclerosis in diabetes mellitus. The purpose of this study was to determine the effects of increased hexosamine biosynthesis pathway (HBP) flux on ER stress levels and the complications of ER stress associated with diabetes and atherosclerosis in hepatic cells. Glutamine:fructose-6-phosphate amidotransferase (GFAT), the rate-limiting enzyme of the HBP, was overexpressed in HepG2 cells by… CONTINUE READING