Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71.

@article{Zhang2015HexonmodifiedRE,
  title={Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71.},
  author={Chao Zhang and Yong Yang and Yudan Chi and Jieyun Yin and Lijun Yan and Zhiqiang Ku and Qingwei Liu and Zhong Huang and Dongming Zhou},
  journal={Vaccine},
  year={2015},
  volume={33 39},
  pages={
          5087-94
        }
}
Hand, foot and mouth disease (HFMD) is a major public health concern in Asia; more efficient vaccines against HFMD are urgently required. Adenoviral (Ad) capsids have been used widely for the presentation of foreign antigens to induce specific immune responses in the host. Here, we describe a novel bivalent vaccine for HFMD based on the hexon-modified, E1-deleted chimpanzee adenovirus serotype 68 (AdC68). The novel vaccine candidate was generated by incorporating the neutralising epitope of… CONTINUE READING
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