Hexobarbitone disposition at different stages of intensive care treatment.

  title={Hexobarbitone disposition at different stages of intensive care treatment.},
  author={I. Rietbrock and Gerald Lazarus and E. -I. Richter and D. D. Breimer},
  journal={British journal of anaesthesia},
  volume={53 3},
The pharmacokinetics of hexobarbitone were investigated in 22 patients in an intensive care unit. The results were compared with those obtained in a healthy group for three time periods: 3rd or 4th day (I), 5-8th days (II) and 13-29th days (III) of treatment. Hexobarbitone 7.32 mg per kg of body weight was administered by i.v. infusion in 60 min. At the end of the infusion, the mean plasma concentration of group I was 71% greater than control group; groups II and III were near to control. In… CONTINUE READING
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