Hexamidine salts – applications in skin health and personal care products

@article{Parisi2017HexamidineS,
  title={Hexamidine salts – applications in skin health and personal care products},
  author={N Parisi and Paul Matts and Rebecca Lever and Jonathan Hadgraft and Majella E Lane},
  journal={International Journal of Cosmetic Science},
  year={2017},
  volume={39}
}
  • N. ParisiP. Matts M. Lane
  • Published 1 August 2017
  • Biology, Chemistry
  • International Journal of Cosmetic Science
Hexamidine (HEX) has been used as a preservative in topical preparations since the 1950s. A number of studies also indicate that the molecule plays a beneficial role in skin homoeostasis. In this review, we describe the physicochemical properties of hexamidine diisethionate (HEX D) and the corresponding hydrochloride salt (HEX H). The biocidal and protease inhibition properties of HEX are outlined as well as the effects of HEX on lipid processing enzymes, corneocyte maturity, stratum corneum… 
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