Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase.

@article{Biswas2008HexamericRS,
  title={Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase.},
  author={Tapan Biswas and Oleg V. Tsodikov},
  journal={The FEBS journal},
  year={2008},
  volume={275 12},
  pages={3064-71}
}
Hexameric DnaB helicase unwinds the DNA double helix during replication of genetic material in bacteria. DnaB is an essential bacterial protein; therefore, it is an important potential target for antibacterial drug discovery. We report a crystal structure of the N-terminal region of DnaB from the pathogen Mycobacterium tuberculosis (MtDnaBn), determined at 2.0 A resolution. This structure provides atomic resolution details of formation of the hexameric ring of DnaB by two distinct interfaces… CONTINUE READING