Hexameric calgranulin C (S100A12) binds to the receptor for advanced glycated end products (RAGE) using symmetric hydrophobic target-binding patches.

@article{Xie2007HexamericCC,
  title={Hexameric calgranulin C (S100A12) binds to the receptor for advanced glycated end products (RAGE) using symmetric hydrophobic target-binding patches.},
  author={Jingjing Xie and David S. Burz and Wei He and Igor B. Bronstein and Igor K. Lednev and Alexander Shekhtman},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 6},
  pages={4218-31}
}
Calgranulin C (S100A12) is a member of the S100 family of proteins that undergoes a conformational change upon calcium binding allowing them to interact with target molecules and initiate biological responses; one such target is the receptor for advanced glycation products (RAGE). The RAGE-calgranulin C interaction mediates a pro-inflammatory response to cellular stress and can contribute to the pathogenesis of inflammatory lesions. The soluble extracellular part of RAGE (sRAGE) was shown to… CONTINUE READING
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