Hexagonal assembly of a restricting TRIM5alpha protein.

@article{GanserPornillos2011HexagonalAO,
  title={Hexagonal assembly of a restricting TRIM5alpha protein.},
  author={Barbie K Ganser-Pornillos and Viswanathan Chandrasekaran and Owen Pornillos and Joseph Sodroski and Wesley I. Sundquist and Mariah Yeager},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 2},
  pages={
          534-9
        }
}
TRIM5α proteins are restriction factors that protect mammalian cells from retroviral infections by binding incoming viral capsids, accelerating their dissociation, and preventing reverse transcription of the viral genome. Individual TRIM5 isoforms can often protect cells against a broad range of retroviruses, as exemplified by rhesus monkey TRIM5α and its variant, TRIM5-21R, which recognize HIV-1 as well as several distantly related retroviruses. Although capsid recognition is not yet fully… CONTINUE READING
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