Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation.

  title={Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation.},
  author={R. Mason and W Rodbumrung and Peter P. Antich},
  journal={NMR in biomedicine},
  volume={9 3},
We have surveyed the sensitivity of the spin lattice relaxation rates of the 19F resonances of several perfluorocarbons to changes in oxygen tension and temperature. Hexafluorobenzene was found to exhibit exceptional sensitivity to changes in oxygen tension, and we have exploited this phenomenon to measure tumor oxygen tension following intratumoral injection. When 20 microliters hexaflourobenzene were injected they remained localized and the biodistribution was readily assessed on the basis of… CONTINUE READING


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