Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation.

@article{Mason1996HexafluorobenzeneAS,
  title={Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation.},
  author={R. Mason and W Rodbumrung and Peter P. Antich},
  journal={NMR in biomedicine},
  year={1996},
  volume={9 3},
  pages={125-34}
}
We have surveyed the sensitivity of the spin lattice relaxation rates of the 19F resonances of several perfluorocarbons to changes in oxygen tension and temperature. Hexafluorobenzene was found to exhibit exceptional sensitivity to changes in oxygen tension, and we have exploited this phenomenon to measure tumor oxygen tension following intratumoral injection. When 20 microliters hexaflourobenzene were injected they remained localized and the biodistribution was readily assessed on the basis of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Molecular imaging of hypoxia.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine • 2008
View 9 Excerpts
Highly Influenced

Functional MRI and CT biomarkers in oncology

European Journal of Nuclear Medicine and Molecular Imaging • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…