Hexafluorine vs. Standard Decontamination to Reduce Systemic Toxicity After Dermal Exposure to Hydrofluoric Acid
@article{Hultn2004HexafluorineVS, title={Hexafluorine vs. Standard Decontamination to Reduce Systemic Toxicity After Dermal Exposure to Hydrofluoric Acid}, author={Peter Hult{\'e}n and Jonas H{\"o}jer and Ulf Ludwigs and Alfons Janson}, journal={Journal of Toxicology: Clinical Toxicology}, year={2004}, volume={42}, pages={355 - 361} }
Introduction. Dermal exposure to hydrofluoric acid (HF) may cause severe burns and systemic toxicity. Hexafluorine® (Prevor, France) is a product marketed as an emergency decontamination fluid for HF skin and eye exposures. Documentation concerning Hexafluorine is scanty, and a recent study indicates that its ability to reduce HF burns is at most equal to that of water. Objective. The present study was conducted to evaluate Hexafluorine's capacity to reduce HF‐induced systemic toxicity. Methods…
17 Citations
Hexafluorine decontamination of 70% hydrofluoric acid (HF) vapor facial exposure: Case report
- Medicine
- 2012
Skin decontamination procedures against potential hazards substances exposure.
- MedicineChemico-biological interactions
- 2021
Hydrofluoric Acid: Burns and Systemic Toxicity, Protective Measures, Immediate and Hospital Medical Treatment
- MedicineOpen access Macedonian journal of medical sciences
- 2018
This review highlights the mechanism of action, presents the acute and chronic symptoms, personal and general protective measures and devices that should be used, as well as decontamination procedures, immediate, antidote and hospital medical treatment.
Water-based solutions are the best decontaminating fluids for dermal corrosive exposures: A mini review
- MedicineClinical toxicology
- 2013
The data support water as the best decontaminating solution, which has been shown to be efficacious in clinical trials, is widely available, and inexpensive.
Chapter 104: Hydrofluoric Acid and Fluorides
- Medicine
- 2019
The actual number of work-related poisonings from HF appears difficult to quantitate because of limitations in International Classification of Diseases (ICD) medical coding and the lack of notification of regional poison control centers by worksites.
Topical Treatment of Experimental Hydrofluoric Acid Skin Burns by 2.5% Calcium Gluconate
- MedicineJournal of burn care & research : official publication of the American Burn Association
- 2006
Repeated applications of a 2.5% calcium gluconate gel is an efficient treatment of experimental 40% hydrofluoric acid skin burn; few differences were observed between evaluated gel formulations.
Recommended Medical Treatment for Hydrofluoric Acid Exposure
- Medicine
- 2006
This Booklet describes the special First Aid and Medical Treatment measures necessary following exposure to or injury from HYDROFLUORIC ACID. PREVENTION of exposure or injury must be the primary…
Calcium, magnesium and aluminium ions as decontaminating agents against dermal fluoride absorption following hydrofluoric acid exposure.
- BiologyToxicology in vitro : an international journal published in association with BIBRA
- 2020
Part 2. Comparison of emergency washing solutions in 70% hydrofluoric acid-burned human skin in an established ex vivo explants model
- MedicineCutaneous and ocular toxicology
- 2011
Background: Hydrofluoric acid (HF) is a small and partially dissociated acid (pKa 3.2), able to deeply penetrate into human skin in addition to the corrosiveness of the hydrogen ion (H+) and the…
Updates on the evaluation and management of caustic exposures.
- MedicineEmergency medicine clinics of North America
- 2007
References
SHOWING 1-10 OF 26 REFERENCES
Hydrofluoric acid dermal exposure.
- MedicineVeterinary and human toxicology
- 1989
Treatment with topical calcium gluconate gel may be effective, and more rapid resolution of signs and symptoms may occur with earlier initiation of this therapy, according to a retrospective review of dermal exposure to dilute (6-11%) hydrofluoric acid (HF)- containing rust stain remover consumer products.
Hydrofluoric Acid‐Induced Burns and Life‐Threatening Systemic Poisoning—Favorable Outcome After Hemodialysis
- MedicineJournal of toxicology. Clinical toxicology
- 2003
Hemodialysis may be an effective and potentially lifesaving additional treatment for severe exposure to HF when standard management has proven insufficient and the rationale for performing hemodialysis for this purpose is clear.
Hydrofluoric acid dermal burns. An assessment of treatment efficacy using an experimental pig model.
- MedicineJournal of occupational medicine. : official publication of the Industrial Medical Association
- 1992
This study suggests that the anesthetized pig model has good applicability for assessing efficacy of HF dermal burn therapies, and indicates that further experimentation with 10% calcium acetate soaks is warranted.
Existing Evidence Does Not Support the Use of Hexafluorine
- Medicine
- 2003
The Prevor Group writes that it would be highly unlikely that any decontamination measure would be efficacious after a 3-min contact duration of 50% HF, and that what the authors actually studied was treatment with topical calcium gluconate, which is incorrect.
Studies on the treatment of hydrofluoric acid burn.
- MedicineBulletin of the Osaka Medical College
- 1989
The results indicate that an HF skin burn results in systemic fluoride poisoning followed by hypocalcemia, hypersecretion of PTH, hyponatremia, hyperkalemia and other electrolytes imbalance.
Therapeutic effect of topical calcium gluconate for hydrofluoric acid burn--time limit for the start of the treatment.
- MedicineJournal of UOEH
- 1999
It is suggested that practitioners should be ready to prepare quickly the calcium gluconate ointment to treat a HF burn, since the calciumgluconates is not commercially available in Japan.
Comparative effectiveness of topical treatments for hydrofluoric acid burns.
- MedicineJournal of occupational medicine. : official publication of the Industrial Medical Association
- 1985
Calcium gluconate ointment was the most effective topical treatment for HF burns and significant protection continued for seven days after the single application.
Medical management of hydrofluoric acid exposure.
- MedicineJournal of occupational medicine. : official publication of the Industrial Medical Association
- 1990
Inhalation, ingestion, and ocular exposures require specialized treatment and referral, and life-threatening alterations of electrolytes can occur, with ensuing arrhythmias.
Comparison of topical magnesium and calcium treatment for dermal hydrofluoric acid burns.
- MedicineAnnals of emergency medicine
- 1994
Fatality due to acute systemic fluoride poisoning following a hydrofluoric acid skin burn.
- MedicineJournal of occupational medicine. : official publication of the Industrial Medical Association
- 1980
A fatality resulting from a severe facial burn, which produced acute systemic fluoride poisoning with profound hypocalcemia and hypomagnesemia, is presented.