Hexadecylphosphocholine inhibits phosphatidylcholine synthesis via both the methylation of phosphatidylethanolamine and CDP-choline pathways in HepG2 cells.

@article{JimnezLpez2004HexadecylphosphocholineIP,
  title={Hexadecylphosphocholine inhibits phosphatidylcholine synthesis via both the methylation of phosphatidylethanolamine and CDP-choline pathways in HepG2 cells.},
  author={Jos{\'e} M. Jim{\'e}nez-L{\'o}pez and Maria Paz Carrasco and Josefa L. Segovia and Carmen Marco},
  journal={The international journal of biochemistry & cell biology},
  year={2004},
  volume={36 1},
  pages={153-61}
}
We reported in a recent publication that hexadecylphosphocholine (HePC), a lysophospholipid analogue, reduces cell proliferation in HepG2 cells and at the same time inhibits the biosynthesis of phosphatidylcholine (PC) via CDP-choline by acting upon CTP:phosphocholine cytidylyltransferase (CT). We describe here the results of our study into the influence of HePC on other biosynthetic pathways of glycerolipids. HePC clearly decreased the incorporation of the exogenous precursor [1,2,3-3H… CONTINUE READING
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