Hexadecylphosphocholine induces a differential pattern of KI- and HA-RAS expression in two human carcinoma cell lines

Abstract

Human ovarian carcinoma cells EFO-27 recovering from antiproliferative doses of antineoplastic phospholipids (Int J Oncol 5: 517-23, 1994) were used to establish a chemoresistant subpopulafion. Longterm incubation with octadecyl-phospho-dimethyl-piperidin (OPP), a derivative of hexadecylphosphocholine (HPC), led to selection of a substrain (EFO-27R20) with… (More)
DOI: 10.1007/BF02572188

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