Hexabromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats.

@article{Miller2016HexabromocyclododecaneI,
  title={Hexabromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats.},
  author={I. George Miller and Tommaso Serchi and S{\'e}bastien Cambier and Coos Diepenbroek and Jenny Renaut and J H J Van der Berg and Christiaan J. A. F. Kwadijk and Arno Christian Gutleb and Eddy Rijntjes and A J Murk},
  journal={Toxicology letters},
  year={2016},
  volume={245},
  pages={40-51}
}
Hexabromocyclododecane (HBCD) is a brominated flame retardant known for its low acute toxicity as observed in animal experiments. However, HBCD exposure can affect liver functioning and thyroid hormone (TH) status. As exact mechanisms are unknown and only limited toxicological data exists, a gel-based proteomic approach was undertaken. In a eu- and hypothyroid female rat model, rats were exposed to 3 and 30 mg/kg bw/day HBCD for 7 days via their diet, and exposure was related to a range of… CONTINUE READING
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