Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins.

@article{Barr2008HeterozygousRM,
  title={Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins.},
  author={Alasdair M Barr and Kenneth N. Fish and Athina Markou and William Honer},
  journal={The European journal of neuroscience},
  year={2008},
  volume={27 10},
  pages={2568-74}
}
Post mortem, reduced brain reelin is noted in schizophrenia. Accordingly, the reelin-haploinsufficient heterozygous reeler mouse (HRM) has been posited as a murine model of the illness. One study reported that HRM exhibit deficits in prepulse inhibition (PPI) of the acoustic startle reflex, a sensorimotor-gating behavior that is disrupted in schizophrenia, although this finding has not been reproduced. To extend the characterization of putative sensorimotor-gating deficits in HRM, these mice… CONTINUE READING