Heterozygous null mutation of myelin P0 protein enhances susceptibility to autoimmune neuritis targeting P0 peptide.

@article{Miyamoto2003HeterozygousNM,
  title={Heterozygous null mutation of myelin P0 protein enhances susceptibility to autoimmune neuritis targeting P0 peptide.},
  author={Katsuichi Miyamoto and Sachiko Miyake and Melitta Schachner and Takashi Yamamura},
  journal={European journal of immunology},
  year={2003},
  volume={33 3},
  pages={656-65}
}
Mice with a heterozygous null mutation in myelin protein zero (P0(+/-)) develop late-onset clinical paralysis associated with inflammatory pathology in the peripheral nerves. Although the development of this illness is known to require T cells and macrophages, little is understood regarding the immunological defect in the mice. Here we report that young P0(+/-) mice, free from clinical manifestations, have a defect in central tolerance to P0, and are more prone to induction of experimental… CONTINUE READING

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