Heterozygous mice for TGF-betaIIR gene are resistant to the progression of streptozotocin-induced diabetic nephropathy.

@article{Kim2004HeterozygousMF,
  title={Heterozygous mice for TGF-betaIIR gene are resistant to the progression of streptozotocin-induced diabetic nephropathy.},
  author={Hwal Woong Kim and Bong Cho Kim and Chi Young Song and Ji Hoon Kim and Hye Kyoung Hong and Hyun Soon Lee},
  journal={Kidney international},
  year={2004},
  volume={66 5},
  pages={
          1859-65
        }
}
BACKGROUND Transforming growth factor-beta (TGF-beta) receptor complex and its downstream Smad signaling intermediates constitute an extracellular matrix (ECM) accumulation pathway. METHODS In the present study, we examined whether decreased expression of the TGF-beta type II receptor (TGF-betaIIR) in TGF-betaIIR gene heterozygous (TGF-betaIIR+/-) (HT) mice could inhibit the Smad signaling pathway and subsequent progression of renal lesions when streptozotocin (STZ) diabetes is induced… CONTINUE READING
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