Heterozygous knock-Out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse.

@article{Berthiaume2000HeterozygousKO,
  title={Heterozygous knock-Out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse.},
  author={Nathalie Berthiaume and Masashi Yanagisawa and Julie Labont{\'e} and Pedro D'Orl{\'e}ans-Juste},
  journal={Hypertension},
  year={2000},
  volume={36 6},
  pages={
          1002-7
        }
}
Homozygous knock-out of ET(A) or ET(B) receptor genes results in lethal developmental phenotypes in the mouse. Such deleterious phenotypes do not occur in heterozygous littermates. However, it remains to be determined whether mice partially defective in ET(A) or ET(B) receptors display significant alterations in their responses to exogenous or endogenous endothelin-1 (ET-1). Furthermore, the anesthetized ET(B) (+/-) knock-out mice showed a significantly higher mean arterial blood pressure than… CONTINUE READING
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