Heterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway.

Abstract

Mutations in the NF1 tumor suppressor gene cause Neurofibromatosis type 1 (NF1). Neurofibromin, the protein product of NF1, functions as a negative regulator of Ras activity. Some NF1 patients develop cardiovascular disease, which represents an underrecognized disease complication and contributes to excess morbidity and mortality. Specifically, NF1 patients… (More)
DOI: 10.1093/hmg/dds502

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Cite this paper

@article{Stansfield2013HeterozygousIO, title={Heterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway.}, author={Brian K Stansfield and Waylan K Bessler and Raghuveer Singh Mali and Julie A. Mund and Brandon D Downing and Fang Li and Kara N Sarchet and Matthew R Distasi and Simon J. Conway and Reuben Kapur and D. Ingram}, journal={Human molecular genetics}, year={2013}, volume={22 5}, pages={977-88} }