Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice.

@article{Iwanaga2007HeterozygousDO,
  title={Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice.},
  author={Yoichi Iwanaga and Ya-hui Chi and Akiko Miyazato and Sergey V Sheleg and Kerstin Haller and Jean-Marie P{\'e}lopon{\`e}se and Yan Li and Jerrold M Ward and Robert Benezra and K T Jeang},
  journal={Cancer research},
  year={2007},
  volume={67 1},
  pages={160-6}
}
Mitotic arrest-deficient protein 1 (MAD1) is a component of the mitotic spindle assembly checkpoint. We have created a knockout mouse model to examine the physiologic consequence of reduced MAD1 function. Mad1(+/-) mice were successfully generated, but repeated paired mating of Mad1(+/-) with Mad1(+/-) mice failed to produce a single Mad1(-/-) animal, suggesting that the latter genotype is embryonic lethal. In aging studies conducted for >18 months, Mad1(+/-) mice compared with control wild… CONTINUE READING

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