Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts

  title={Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts},
  author={Qingxian Lu and Yingnan Zhang and Ramesh B. Kasetti and Subhash Gaddipati and Naresh Kumar Cvm and Douglas Borchman and Qiutang Li},
  journal={Investigative Ophthalmology \& Visual Science},
Purpose Yap1 encodes an evolutionarily conserved transcriptional coactivator and functions as a down-stream effector of the Hippo signaling pathway that controls tissue size and cell growth. Yap1 contributes to lens epithelial development. However, the effect of Yap1 haplodeficiency on the lens epithelium and its role in the development of cataracts has not been reported. The aim of the current study is to investigate Yap1 function and its regulatory mechanisms in lens epithelial cells (LECs… 

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