Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts

@article{Lu2020HeterozygousLO,
  title={Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts},
  author={Qingxian Lu and Yingnan Zhang and Ramesh B. Kasetti and Subhash Gaddipati and Naresh Kumar Cvm and Douglas Borchman and Qiutang Li},
  journal={Investigative Ophthalmology \& Visual Science},
  year={2020},
  volume={61}
}
Purpose Yap1 encodes an evolutionarily conserved transcriptional coactivator and functions as a down-stream effector of the Hippo signaling pathway that controls tissue size and cell growth. Yap1 contributes to lens epithelial development. However, the effect of Yap1 haplodeficiency on the lens epithelium and its role in the development of cataracts has not been reported. The aim of the current study is to investigate Yap1 function and its regulatory mechanisms in lens epithelial cells (LECs… 

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References

SHOWING 1-10 OF 65 REFERENCES

Deficiency of Yes-Associated Protein Induces Cataract in Mice

Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is

Crim1 is required for maintenance of the ocular lens epithelium

Crim1 regulates integrin signaling in murine lens development

It is shown that Crim1 acts in LE cells, where it colocalizes with and regulates the levels of active β1 integrin and of phosphorylated FAK and ERK and the RGD and transmembrane motifs of Crim1 are required for regulating FAK phosphorylation.

Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants

Results reveal that CNN3 plays a crucial role in regulating lens epithelial contractile activity and provide supporting evidence that CNN-3 deficiency is associated with the induction of epithelial plasticity, fibrogenic activity and mechanosensitive Yap/Taz transcriptional activation.

Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65

In vivo requirements for YAP are revealed in the developmental processes of yolk sac vasculogenesis, chorioallantoic attachment, and embryonic axis elongation.

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

A role for Yes-associated protein (YAP) is demonstrated in maintaining basal epidermal progenitors and regulating HF morphogenesis and a requirement for TEA domain (TEAD) transcriptional factors to comediate YAP functions in MKs is demonstrated.
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