Heterozygote advantage fails to explain the high degree of polymorphism of the MHC

@article{Boer2003HeterozygoteAF,
  title={Heterozygote advantage fails to explain the high degree of polymorphism of the MHC},
  author={Rob J. De Boer and Jos{\'e} A. M. Borghans and Michiel van Boven and Can Kesmir and Franz J. Weissing},
  journal={Immunogenetics},
  year={2003},
  volume={55},
  pages={725-731}
}
Major histocompatibility (MHC) molecules are encoded by extremely polymorphic genes and play a crucial role in vertebrate immunity. Natural selection favors MHC heterozygous hosts because individuals heterozygous at the MHC can present a larger diversity of peptides from infectious pathogens than homozygous individuals. Whether or not heterozygote advantage is sufficient to account for a high degree of polymorphism is controversial, however. Using mathematical models we studied the degree of… CONTINUE READING
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