Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice.

@article{Leland2009HeterozygosityFA,
  title={Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice.},
  author={Shawn Leland and Prabakaran Nagarajan and Aris Polyzos and Sharon T. Thomas and George Samaan and Robert Mc Donnell and Francesco Marchetti and Sundaresan Venkatachalam},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 31},
  pages={12776-81}
}
Aneuploidy, the most common chromosomal abnormality at birth and the main ascertained cause of pregnancy loss in humans, originates primarily from chromosome segregation errors during oogenesis. Here, we report that heterozygosity for a mutation in the mitotic checkpoint kinase gene, Bub1, induces aneuploidy in female germ cells of mice and that the effect increases with advancing maternal age. Analysis of Bub1 heterozygous oocytes showed that aneuploidy occurred primarily during the first… CONTINUE READING

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Aneuploidy , the most common chromosomal abnormality at birth and the main ascertained cause of pregnancy loss in humans , originates primarily from chromosome segregation errors during oogenesis .
Aneuploidy , the most common chromosomal abnormality at birth and the main ascertained cause of pregnancy loss in humans , originates primarily from chromosome segregation errors during oogenesis .
Furthermore , aneuploidy was inherited in zygotes and resulted in the loss of embryos after implantation .
Furthermore , aneuploidy was inherited in zygotes and resulted in the loss of embryos after implantation .
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