Heterozygosity at polymorphic codon 219 in variant creutzfeldt-jakob disease.

@article{Luki2010HeterozygosityAP,
  title={Heterozygosity at polymorphic codon 219 in variant creutzfeldt-jakob disease.},
  author={Ana Luki{\'c} and Jonathan Beck and Susan Joiner and Julian Fearnley and Steve Sturman and Sebastian Brandner and Jonathan D F Wadsworth and John Collinge and Shepherd Mead},
  journal={Archives of neurology},
  year={2010},
  volume={67 8},
  pages={
          1021-3
        }
}
BACKGROUND Genetic variants of the prion protein gene (PRNP) strongly determine susceptibility to prion diseases. All tested patients with definite variant Creutzfeldt-Jakob disease (vCJD) are homozygous for methionine at a common polymorphism at codon 129. A further genetic polymorphism at codon 219, a common variant in several Asian populations, is considered protective against sporadic CJD. OBJECTIVE To report a finding of heterozygosity at codon 219 in 2 patients with vCJD. DESIGN Case… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

An overview of human prion diseases

  • Virology Journal
  • 2011
VIEW 2 EXCERPTS
CITES BACKGROUND

Infectious causes of rapidly progressive dementia.

  • Seminars in neurology
  • 2011
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 15 REFERENCES

Molecular neurology of prion disease.

  • Journal of neurology, neurosurgery, and psychiatry
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL