Heterotypic recognition of recombinant FMDV proteins by bovine T-cells: the polymerase (P3Dpol) as an immunodominant T-cell immunogen.

@article{Collen1998HeterotypicRO,
  title={Heterotypic recognition of recombinant FMDV proteins by bovine T-cells: the polymerase (P3Dpol) as an immunodominant T-cell immunogen.},
  author={Trevor Collen and J Baron and A J Childerstone and Amanda Corteyn and Timothy Doel and Mike Flint and M Garcia-Valcarcel and R Michael E Parkhouse and Martin D Ryan},
  journal={Virus research},
  year={1998},
  volume={56 2},
  pages={
          125-33
        }
}
In this study we have examined the recognition of VP0, VP1, VP2, VP3 and P3Dpol by PBMC and CD4+ T-cells from infected, vaccinated-challenged, and multiply-vaccinated (O1, A24, C1 or ASIA1) cattle using recombinant proteins of an O1 serotype virus. The structural protein VP1 was recognised in an homotypic context whereas VP2, VP3, VP4 and P3Dpol were also recognised by T-cells from animals exposed to heterotypic viruses. Only the non-structural protein P3Dpol was consistently recognised by T… CONTINUE READING
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