Heterotypic cell-cell adhesion of human mast cells to fibroblasts

  title={Heterotypic cell-cell adhesion of human mast cells to fibroblasts},
  author={Axel Trautmann and Bernadette Feuerstein and Norman Ernst and E Br{\"o}cker and C. Eberhard Klein},
  journal={Archives of Dermatological Research},
Skin mast cells are typically located in the perivascular or perineural connective tissue. We observed that HMC-1 mast cells growing in suspension adhered efficiently to (> 90% of cells) and spread on top of fibroblast monolayers and to a lesser degree on purified extracellular matrix proteins. Since adhesive interactions determine cell migration and tissue localization we studied the mechanism. It was found that HMC-1 cells attach to collagen I and fibronectin, laminin, collagen IV and… CONTINUE READING


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