Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages.

@article{Arif2012HeterotrimericGC,
  title={Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages.},
  author={Abul Arif and Piyali Chatterjee and Robyn A Moodt and Paul L. Fox},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 24},
  pages={5046-55}
}
The gamma interferon (IFN-γ)-activated inhibitor of translation (GAIT) complex in human myeloid cells is heterotetrameric, consisting of glutamyl-prolyl-tRNA synthetase (EPRS), NS1-associated protein 1 (NSAP1), ribosomal protein L13a, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The complex binds a structural GAIT element in the 3' untranslated region of VEGF-A and other inflammation-related transcripts and inhibits their translation. EPRS is dually phosphorylated by cyclin-dependent… CONTINUE READING
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