Heterotrimeric G-proteins interact directly with cytoskeletal components to modify microtubule-dependent cellular processes.

@article{Dav2009HeterotrimericGI,
  title={Heterotrimeric G-proteins interact directly with cytoskeletal components to modify microtubule-dependent cellular processes.},
  author={Rahul H Dav{\'e} and Witchuda Saengsawang and J. Yu and Robert J Donati and Mark M. Rasenick},
  journal={Neuro-Signals},
  year={2009},
  volume={17 1},
  pages={100-8}
}
A large percentage of current drugs target G-protein-coupled receptors, which couple to well-known signaling pathways involving cAMP or calcium. G-proteins themselves may subserve a second messenger function. Here, we review the role of tubulin and microtubules in directly mediating effects of heterotrimeric G-proteins on neuronal outgrowth, shape and differentiation. G-protein-tubulin interactions appear to be regulated by neurotransmitter activity, and, in turn, regulate the location of… CONTINUE READING
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