Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells.

@article{Rebois2006HeterotrimericGP,
  title={Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells.},
  author={R. Victor Rebois and M{\'e}lanie Robitaille and C{\'e}line Gal{\'e}s and Denis J Dupr{\'e} and Alessandra Baragli and Phan Trieu and Nathalie Ethier and Michel Bouvier and Terence E. H{\'e}bert},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 13},
  pages={
          2807-18
        }
}
Bioluminescence resonance energy transfer (BRET) and co-immunoprecipitation experiments revealed that heterotrimeric G proteins and their effectors were found in stable complexes that persisted during signal transduction. Adenylyl cyclase, Kir3.1 channel subunits and several G-protein subunits (Galpha(s), Galpha(i), Gbeta(1) and Ggamma(2)) were tagged with luciferase (RLuc) or GFP, or the complementary fragments of YFP (specifically Gbeta(1)-YFP(1-158) and Ggamma(2)-YFP(159-238), which… CONTINUE READING

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